Luca Della Santina, PhD

Assistant Professor, Ophthalmology

Scalable method for micro-CT analysis enables large scale quantitative characterization of brain lesions and implants.

Scientific reports

Kastner DB, Kharazia V, Nevers R, Smyth C, Astudillo-Maya DA, Williams GM, Yang Z, Holobetz CM, Santina LD, Parkinson DY, Frank LM

Probing ON and OFF Retinal Pathways in Glaucoma Using Electroretinography.

Translational vision science & technology

Kong AW, Della Santina L, Ou Y

A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse.


Maddox JW, Randall KL, Yadav RP, Williams B, Hagen J, Derr PJ, Kerov V, Della Santina L, Baker SA, Artemyev N, Hoon M, Lee A

Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors.

Cell reports

Care RA, Anastassov IA, Kastner DB, Kuo YM, Della Santina L, Dunn FA

Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit.

Cell reports

Care RA, Kastner DB, De la Huerta I, Pan S, Khoche A, Della Santina L, Gamlin C, Santo Tomas C, Ngo J, Chen A, Kuo YM, Ou Y, Dunn FA

Biolistic Labeling of Retinal Ganglion Cells.

Methods in molecular biology (Clifton, N.J.)

Santina LD, Ou Y

Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L

Glutamatergic Monopolar Interneurons Provide a Novel Pathway of Excitation in the Mouse Retina.

Current biology : CB

Della Santina L, Kuo SP, Yoshimatsu T, Okawa H, Suzuki SC, Hoon M, Tsuboyama K, Rieke F, Wong ROL

Involvement of Autophagic Pathway in the Progression of Retinal Degeneration in a Mouse Model of Diabetes.

Frontiers in cellular neuroscience

Piano I, Novelli E, Della Santina L, Strettoi E, Cervetto L, Gargini C

TMEM16A is associated with voltage-gated calcium channels in mouse retina and its function is disrupted upon mutation of the auxiliary a2d4 subunit.

Frontiers in cellular neuroscience

Caputo A, Piano I, Demontis GC, Bacchi N, Casarosa S, Della Santina L, Gargini C

Illuminating the multifaceted roles of neurotransmission in shaping neuronal circuitry.


Okawa H, Hoon M, Yoshimatsu T, Della Santina L, Wong ROL

Functional architecture of the retina: development and disease.

Progress in retinal and eye research

Hoon M, Okawa H, Della Santina L, Wong RO

Sensory experience shapes the development of the visual system's first synapse.


Dunn FA, Della Santina L, Parker ED, Wong RO

Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Della Santina L, Inman DM, Lupien CB, Horner PJ, Wong RO

Processing of retinal signals in normal and HCN deficient mice.

PloS one

Della Santina L, Piano I, Cangiano L, Caputo A, Ludwig A, Cervetto L, Gargini C

Effect of HCN channel inhibition on retinal morphology and function in normal and dystrophic rodents.

Investigative ophthalmology & visual science

Della Santina L, Bouly M, Asta A, Demontis GC, Cervetto L, Gargini C

Prolonged illumination up-regulates arrestin and two guanylate cyclase activating proteins: a novel mechanism for light adaptation.

The Journal of physiology

Codega P, Della Santina L, Gargini C, Bedolla DE, Subkhankulova T, Livesey FJ, Cervetto L, Torre V

High-pass filtering of input signals by the Ih current in a non-spiking neuron, the retinal rod bipolar cell.

PloS one

Cangiano L, Gargini C, Della Santina L, Demontis GC, Cervetto L