Peder Larson, PhD

Associate Professor
Radiology
+1 415 514-4876

Peder Larson, PhD, is an Associate Professor in Residence and a Principal Investigator in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Larson's research program includes a range of imaging technology development targeting improved clinical outcomes, with projects on metabolic MRI, lung MRI, myelin imaging, PET/MRI, and radiation therapy planning:

Metabolic imaging methods using hyperpolarized carbon-13 MRI
This technology uses non-toxic, non-ionizing contrast agents to provide unique metabolism information, and is currently in clinical trials. Our team develops data acquisition, image reconstruction, and data analysis methods for this technology for a broad range of collaborators and applications. We are also leading new patient studies of this technology in renal cancers and heart disease.

Lung MRI
Conventional MRI performs very poorly in the lungs but our team has developed methods based on ultrashort echo time (UTE) MRI to provide high quality, high-resolution lung MRI. We are pursuing development of functional imaging biomarkers and translation onto clinical MRI scanners, with a focus on pediatric studies to reduce radiation dose compared to CT.

Myelin MRI
Our team has pioneered a new MRI approach for direct imaging of myelin based on ultrashort echo time (UTE) MRI. Other MRI methods provide indirect myelin measurements based measurements on nearby water. We are continuing to develop this technique as a quantitative imaging method, and translating into studies evaluating myelination in disease.

PET/MRI
Hybrid PET/MRI systems combine the functional information from PET tracers with the soft-tissue contrast from MRI. Our team is working on PET/MRI technology developments for motion management, quantitative imaging, and multi-modal data analysis with this modality.

Radiation Therapy PLanning
Applications of MRI in radiotherapy have increased significantly over the past decade due to the high level of soft tissue provided, often allowing for better visualization of tumors and organs at risk versus computed tomography (CT). Our team is working to develop specialized MR techniques to accurately estimate parameters used for radiotherapy dose calculation as a critical step towards MRI-only treatment planning.

Dr. Larson is an active member of International Society for Magnetic Resonance in Medicine, the Institute for Electrical and Electronics Engineering, the UC Berkeley and UCSF Graduate Group in Bioengineering, the California Institute for Quantitative Biosciences, and the Bakar Institute for Computational Health Sciences.

Publications: 

Utilizing the wavelet transform’s structure in compressed sensing.

Signal, Image and Video Processing

Nicholas Dwork, Daniel O’Connor, Corey A. Baron, Ethan M. I. Johnson, Adam B. Kerr, John M. Pauly, Peder E. Z. Larson

Di-chromatic interpolation of magnetic resonance metabolic images.

Magma (New York, N.Y.)

Dwork N, Gordon JW, Tang S, O'Connor D, Hansen ESS, Laustsen C, Larson PEZ

Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models.

NMR in biomedicine

Ahamed F, Van Criekinge M, Wang ZJ, Kurhanewicz J, Larson P, Sriram R

Non-invasive assessment of telomere maintenance mechanisms in brain tumors.

Nature communications

Viswanath P, Batsios G, Mukherjee J, Gillespie AM, Larson PEZ, Luchman HA, Phillips JJ, Costello JF, Pieper RO, Ronen SM

Predicting Generalization in Deep Learning via Local Measures of Distortion

arXiv

Abhejit Rajagopal, Vamshi C. Madala, Shivkumar Chandrasekaran, Peder E. Z. Larson

Fast variable density Poisson-disc sample generation with directional variation for compressed sensing in MRI.

Magnetic resonance imaging

Dwork N, Baron CA, Johnson EMI, O'Connor D, Pauly JM, Larson PEZ

Proceedings of Machine Learning Research

Breaking Speed Limits with Simultaneous Ultra-Fast MRI Reconstruction and Tissue Segmentation

Francesco Calivá, Andrew P. Leynes, Rutwik Shah, Upasana Upadhyay Bharadwaj, Sharmila Majumdar, Peder E. Z. Larson, Valentina Pedoia

Technical note: A methodology for improved accuracy in stopping power estimation using MRI and CT.

Medical physics

Scholey JE, Chandramohan D, Naren T, Liu W, Larson PEZ, Sudhyadhom A

68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality.

EJNMMI physics

Murthy V, Smith RL, Tao DH, Lawhn-Heath CA, Korenchan DE, Larson PEZ, Flavell RR, Hope TA

Slice profile effects on quantitative analysis of hyperpolarized pyruvate.

NMR in biomedicine

Walker CM, Gordon JW, Xu Z, Michel KA, Li L, Larson PEZ, Vigneron DB, Bankson JA

55 Mn-based fiducial markers for rapid and automated RF coil localization for hyperpolarized 13 C MRI.

Magnetic resonance in medicine

Ohliger MA, Gordon JW, Carvajal L, Larson PEZ, Ou JJ, Agarwal S, Zhu Z, Vigneron DB, von Morze C

A variable resolution approach for improved acquisition of hyperpolarized 13 C metabolic MRI.

Magnetic resonance in medicine

Gordon JW, Autry AW, Tang S, Graham JY, Bok RA, Zhu X, Villanueva-Meyer JE, Li Y, Ohilger MA, Abraham MR, Xu D, Vigneron DB, Larson PEZ

Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma.

NeuroImage. Clinical

Autry AW, Gordon JW, Chen HY, LaFontaine M, Bok R, Van Criekinge M, Slater JB, Carvajal L, Villanueva-Meyer JE, Chang SM, Clarke JL, Lupo JM, Xu D, Larson PEZ, Vigneron DB, Li Y

3D Magnetic Resonance Spirometry.

Scientific reports

Boucneau T, Fernandez B, Larson P, Darrasse L, Maître X

Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI.

Magnetic resonance in medicine

Chen HY, Autry AW, Brender JR, Kishimoto S, Krishna MC, Vareth M, Bok RA, Reed GD, Carvajal L, Gordon JW, van Criekinge M, Korenchan DE, Chen AP, Xu D, Li Y, Chang SM, Kurhanewicz J, Larson PEZ, Vigneron DB

Simultaneous metabolic and perfusion imaging using hyperpolarized 13C MRI can evaluate early and dose-dependent responses to radiotherapy in a prostate cancer mouse model.

International journal of radiation oncology, biology, physics

Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J

In vivo detection of ?-glutamyl-transferase up-regulation in glioma using hyperpolarized ?-glutamyl-[1-13C]glycine.

Scientific reports

Batsios G, Najac C, Cao P, Viswanath P, Subramani E, Saito Y, Gillespie AM, Yoshihara HAI, Larson P, Sando S, Ronen SM

Extreme MRI: Large-scale volumetric dynamic imaging from continuous non-gated acquisitions.

Magnetic resonance in medicine

Ong F, Zhu X, Cheng JY, Johnson KM, Larson PEZ, Vasanawala SS, Lustig M

Hyperpolarized 13 C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco.

NMR in biomedicine

Crane JC, Gordon JW, Chen HY, Autry AW, Li Y, Olson MP, Kurhanewicz J, Vigneron DB, Larson PEZ, Xu D

Bone Material Analogues for PET/MRI Phantoms.

Medical physics

Chandramohan D, Cao P, Han M, An H, Sunderland JJ, Kinahan PE, Laforest R, Hope TA, Larson PEZ

A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-13 C]pyruvate studies on a 3T clinical scanner.

Magnetic resonance in medicine

Tang S, Bok R, Qin H, Reed G, VanCriekinge M, Delos Santos R, Overall W, Santos J, Gordon J, Wang ZJ, Vigneron DB, Larson PEZ

Fast Imaging for Hyperpolarized MR Metabolic Imaging.

Journal of magnetic resonance imaging : JMRI

Gordon JW, Chen HY, Dwork N, Tang S, Larson PEZ

Simultaneous T1 and T2 mapping of hyperpolarized 13C compounds using the bSSFP sequence.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Milshteyn E, Reed GD, Gordon JW, von Morze C, Cao P, Tang S, Leynes AP, Larson PEZ, Vigneron DB

MR-based Attenuation Correction for Brain PET Using 3D Cycle-Consistent Adversarial Network.

IEEE Transactions on Radiation and Plasma Medical Sciences

Kuang Gong, Jaewon Yang, Peder E.Z. Larson, Spencer C. Behr, Thomas A. Hope, Youngho Seo, Quanzheng Li

CBMT-02. UP-REGULATION OF G-GLUTAMYL-TRANSFERASE CAN BE USED TO IMAGE GLIOBLASTOMA USING HYPERPOLARIZED G-GLUTAMYL-[1-13C]GLYCINE MRS.

Neuro-oncology

Georgios Batsios, Chloe Najac, Peng Cao, Pavithra Viswanath, Elavarasan Subramani, Yutaro Saito, Anne Marie Gillespie, Hikari Yoshihara, Peder Larson, Shinsuke Sando, Sabrina Ronen

CBMT-08. IN VIVO EVALUATION OF PENTOSE PHOSPHATE PATHWAY ACTIVITY IN ORTHOTOPIC GLIOMA USING HYPERPOLARIZED d-[1-13C]GLUCONOLACTONE.

Neuro-oncology

Georgios Batsios, Pavithra Viswanath, Peng Cao, Celine Taglang, Elavarasan Subramani, Robert Flavell, Peder Larson, Sabrina Ronen

CBMT-26. SERIAL CHARACTERIZATION OF HYPERPOLARIZED [1-13C]PYRUVATE METABOLISM IN PATIENTS WITH GLIOMA AND THE INFLUENCE OF BEVACIZUMAB.

Neuro-oncology

Adam Autry, Jeremy Gordon, Hsin-Yu Chen, Marisa Lafontaine, Javier Villanueva-Meyer, Susan Chang, Duan Xu, Peder Larson, Daniel Vigneron, Yan Li

CBMT-36. INITIAL EXPERIENCE WITH HYPERPOLARIZED [2-13C]PYRUVATE MR IMAGING IN PATIENTS WITH IDH-MUTANT GLIOMA.

Neuro-oncology

Adam Autry, Brian Chung, Hsin-Yu Chen, Jeremy Gordon, Marisa Lafontaine, Susan Chang, Javier Villanueva-Meyer, Peder Larson, Daniel Vigneron, Yan Li

NIMG-57. SERIAL HYPERPOLARIZED 13C PYRUVATE AND 1H METABOLIC IMAGING IN RECURRENT HIGH-GRADE GLIOMA.

Neuro-oncology

Javier Villanueva-Meyer, Adam Autry, Jeremy Gordon, Hsin-Yu Chen, Marisa Lafontaine, Susan Chang, Duan Xu, Peder Larson, Daniel Vigneron, Yan Li

Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study.

Prostate cancer and prostatic diseases

Chen HY, Aggarwal R, Bok RA, Ohliger MA, Zhu Z, Lee P, Gordon JW, van Criekinge M, Carvajal L, Slater JB, Larson PEZ, Small EJ, Kurhanewicz J, Vigneron DB

First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil M, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB

Technical Note: Simultaneous Segmentation and Relaxometry for MRI through Multitask Learning.

Medical physics

Cao P, Liu J, Tang S, Leynes AP, Lupo JM, Xu D, Larson PEZ

Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain.

IEEE transactions on medical imaging

Mammoli D, Gordon J, Autry A, Larson PEZ, Li Y, Chen HY, Chung B, Shin P, Van Criekinge M, Carvajal L, Slater JB, Bok R, Crane J, Xu D, Chang S, Vigneron DB

Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging.

Magnetic resonance in medicine

Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR

Hyperpolarized 13C MRI: State of the Art and Future Directions.

Radiology

Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB

Effects of excitation angle strategy on quantitative analysis of hyperpolarized pyruvate.

Magnetic resonance in medicine

Walker CM, Fuentes D, Larson PEZ, Kundra V, Vigneron DB, Bankson JA

Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Zhu Z, Zhu X, Ohliger MA, Tang S, Cao P, Carvajal L, Autry AW, Li Y, Kurhanewicz J, Chang S, Aggarwal R, Munster P, Xu D, Larson PEZ, Vigneron DB, Gordon JW

Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging.

NMR in biomedicine

Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ

Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients.

Magnetic resonance in medicine

Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB

Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients.

NMR in biomedicine

Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB

A regional bolus tracking and real-time B1 calibration method for hyperpolarized 13 C MRI.

Magnetic resonance in medicine

Tang S, Milshteyn E, Reed G, Gordon J, Bok R, Zhu X, Zhu Z, Vigneron DB, Larson PEZ

Developing an efficient phase-matched attenuation correction method for quiescent period PET in abdominal PET/MRI.

Physics in medicine and biology

Yang J, Liu J, Wiesinger F, Menini A, Zhu X, Hope TA, Seo Y, Larson PEZ

Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI.

Cancers

Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ

Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging.

Contrast media & molecular imaging

Autry AW, Hashizume R, James CD, Larson PEZ, Vigneron DB, Park I

High-resolution echo-planar spectroscopic imaging at ultra-high field.

NMR in biomedicine

Coello E, Noeske R, Burns BL, Gordon JW, Jakary A, Menze B, Haase A, Larson PEZ, Li Y, Schulte RF

Spatio-Temporally Constrained Reconstruction for Hyperpolarized Carbon-13 MRI Using Kinetic Models.

IEEE transactions on medical imaging

Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson PEZ

Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration.

Spine

Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC

Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences.

Journal of magnetic resonance imaging : JMRI

Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW

MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation.

NeuroImage

Wei H, Cao P, Bischof A, Henry RG, Larson PEZ, Liu C

Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer.

Magnetic resonance in medicine

Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB

Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized 13C imaging using the bSSFP sequence.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Larson PEZ, Vigneron DB

In vivo hyperpolarization transfer in a clinical MRI scanner.

Magnetic resonance in medicine

von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME

Zero TE-based pseudo-CT image conversion in the head and its application in PET/MR attenuation correction and MR-guided radiation therapy planning.

Magnetic resonance in medicine

Wiesinger F, Bylund M, Yang J, Kaushik S, Shanbhag D, Ahn S, Jonsson JH, Lundman JA, Hope T, Nyholm T, Larson P, Cozzini C

3D hyperpolarized C-13 EPI with calibrationless parallel imaging.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Gordon JW, Hansen RB, Shin PJ, Feng Y, Vigneron DB, Larson PEZ

Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.

Magnetic resonance in medicine

Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ

2018 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP):

Synthetic CT Generation Using MRI with Deep Learning: How Does the Selection of Input Images Affect the Resulting Synthetic CT?

Leynes AP, Larson PEZ

MR Pulse Sequences for PET/MRI.

PET/MRI in Oncology

Peder E. Z. Larson, Valentina Taviani

In vivo characterization of brain ultrashort-T2 components.

Magnetic resonance in medicine

Boucneau T, Cao P, Tang S, Han M, Xu D, Henry RG, Larson PEZ

NIMG-64. THE POTENTIAL OF 7T ANATOMICAL IMAGING FOR CLINICAL ASSESSMENT OF CONTRAST-ENHANCING AND T2-HYPERINTENSE LESIONS IN PATIENTS WITH GLIOMA.

Neuro-oncology

Angela Jakary, Christopher Hess, Marisa LaFontaine, Peder Larson, Nicholas Butowski, Jennifer Clarke, Susan Chang, Janine Lupo

PET/MRI: Where might it replace PET/CT?.

Journal of Magnetic Resonance Imaging

Eric C. Ehman, Geoffrey B. Johnson, Javier E. Villanueva-Meyer, Soonmee Cha, Andrew Palmera Leynes, Peder Eric Zufall Larson, Thomas A. Hope

Zero-Echo-Time and Dixon Deep Pseudo-CT (ZeDD CT): Direct Generation of Pseudo-CT Images for Pelvic PET/MRI Attenuation Correction Using Deep Convolutional Neural Networks with Multiparametric MRI.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Leynes AP, Yang J, Wiesinger F, Kaushik SS, Shanbhag DD, Seo Y, Hope TA, Larson PEZ

Shuffled magnetization-prepared multicontrast rapid gradient-echo imaging.

Magnetic resonance in medicine

Cao P, Zhu X, Tang S, Leynes A, Jakary A, Larson PEZ

Reliable and Reproducible GABA Measurements Using Automated Spectral Prescription at Ultra-High Field.

Frontiers in human neuroscience

Li Y, Bian W, Larson P, Crane JC, Parvathaneni P, Nagarajan S, Nelson SJ

Density-weighted concentric rings k-space trajectory for 1 H magnetic resonance spectroscopic imaging at 7 T.

NMR in biomedicine

Chiew M, Jiang W, Burns B, Larson P, Steel A, Jezzard P, Albert Thomas M, Emir UE

Motion robust high resolution 3D free-breathing pulmonary MRI using dynamic 3D image self-navigator.

Magnetic resonance in medicine

Jiang W, Ong F, Johnson KM, Nagle SK, Hope TA, Lustig M, Larson PEZ

Evaluation of Sinus/Edge-Corrected Zero-Echo-Time-Based Attenuation Correction in Brain PET/MRI.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Yang J, Wiesinger F, Kaushik S, Shanbhag D, Hope TA, Larson PEZ, Seo Y

Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging.

The Analyst

Korenchan DE, Taglang C, von Morze C, Blecha JE, Gordon JW, Sriram R, Larson PEZ, Vigneron DB, VanBrocklin HF, Kurhanewicz J, Wilson DM, Flavell RR

Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion.

Cancer research

Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB

Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver.

Journal of magnetic resonance imaging : JMRI

Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA

PET/MRI: Where might it replace PET/CT?

Journal of magnetic resonance imaging : JMRI

Ehman EC, Johnson GB, Villanueva-Meyer JE, Cha S, Leynes AP, Larson PEZ, Hope TA

Hybrid ZTE/Dixon MR-based attenuation correction for quantitative uptake estimation of pelvic lesions in PET/MRI.

Medical physics

Leynes AP, Yang J, Shanbhag DD, Kaushik SS, Seo Y, Hope TA, Wiesinger F, Larson PE

Imaging of the rabbit supraspinatus enthesis at 7 Tesla: a 4-week time course after repair surgery and effect of channeling.

Journal of magnetic resonance imaging : JMRI

Trudel G, Melkus G, Cron GO, Louati H, Sheikh A, Larson PEZ, Schweitzer M, Lapner P, Uhthoff HK, Laneuville O

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.

Magnetic resonance imaging

Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB

High spatiotemporal resolution hyperpolarized 13C angiography.

Critical Reviews in Computed Tomography

Galen D Reed, Cornelius von Morze, Nii O Addy, R Reeve Ingle, Kenneth O Johnson, William R Overall, Bob S Hu, Daniel B Vigneron, Peder E Larson, Juan M Santos

Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.

Magnetic resonance in medicine

Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M

Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses.

Magnetic resonance in medicine

Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PEZ, Pauly JM, Vigneron DB

Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects.

Magnetic resonance in medicine

Gordon JW, Milshteyn E, Marco-Rius I, Ohliger M, Vigneron DB, Larson PEZ

Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PEZ, Kurhanewicz J

Pulse Sequences for Hyperpolarized MRS.

eMagRes

Jeremy W. Gordon, Peder E.Z. Larson

Combining hyperpolarized 13 C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism.

Magnetic resonance in medicine

Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PEZ, Bok R, Chen HY, Kurhanewicz J, Vigneron D

Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.

Tomography (Ann Arbor, Mich.)

Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB

Optimizing Flip Angles for Metabolic Rate Estimation in Hyperpolarized Carbon-13 MRI.

IEEE transactions on medical imaging

Maidens J, Gordon JW, Arcak M, Larson PE

Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing.

Magnetic resonance in medicine

Cao P, Shin PJ, Park I, Najac C, Marco-Rius I, Vigneron DB, Nelson SJ, Ronen SM, Larson PE

Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver.

Magnetic resonance in medicine

von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB

Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies.

Magnetic resonance in medicine

Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB

Ultrashort echo time and zero echo time MRI at 7T.

Magma (New York, N.Y.)

Larson PE, Han M, Krug R, Jakary A, Nelson SJ, Vigneron DB, Henry RG, McKinnon G, Kelley DA

Multiband RF pulses with improved performance via convex optimization.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Shang H, Larson PEZ, Kerr A, Reed G, Sukumar S, Elkhaled A, Gordon JW, Ohliger MA, Pauly JM, Lustig M, Vigneron DB

Assessing temperature dependence of T1 in cortical bone using ultrashort echo-time MRI.

Journal of therapeutic ultrasound

Misung Han, Serena Scott, Eugene Ozhinsky, Vasant Salgaonkar, Peter Jones, Peder Larson, Chris Diederich, Roland Krug, Viola Rieke

1 H-13 C independently tuned radiofrequency surface coil applied for in vivo hyperpolarized MRI.

Magnetic resonance in medicine

Cao P, Zhang X, Park I, Najac C, Nelson SJ, Ronen S, Larson PE

Development and testing of hyperpolarized (13)C MR calibrationless parallel imaging.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Feng Y, Gordon JW, Shin PJ, von Morze C, Lustig M, Larson PEZ, Ohliger MA, Carvajal L, Tropp J, Pauly JM, Vigneron DB

Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function.

American journal of physiology. Renal physiology

Xie L, Layton AT, Wang N, Larson PE, Zhang JL, Lee VS, Liu C, Johnson GA

Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.

Chemical communications (Cambridge, England)

Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM

Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI.

Magnetic resonance in medicine

Han M, Rieke V, Scott SJ, Ozhinsky E, Salgaonkar VA, Jones PD, Larson PE, Diederich CJ, Krug R

Detection of Small Pulmonary Nodules with Ultrashort Echo Time Sequences in Oncology Patients by Using a PET/MR System.

Radiology

Burris NS, Johnson KM, Larson PE, Hope MD, Nagle SK, Behr SC, Hope TA

Dynamic UltraFast 2D EXchange SpectroscopY (UF-EXSY) of hyperpolarized substrates.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Leon Swisher C, Koelsch B, Sukumar S, Sriram R, Santos RD, Wang ZJ, Kurhanewicz J, Vigneron D, Larson P

BT-07MEASURING TUMOR METABOLISM IN DIFFUSE INTRINSIC PONTINE GIOMAS (DIPG) USING HYPERPOLARIZED CARBON-13 MR SPECTROSCOPIC IMAGING.

Neuro-oncology

Ilwoo Park, Rintaro Hashizume, Xiaodong Yang, Peder Larson, C. David James, Daniel Vigneron, Sabine Mueller, Sarah Nelson

Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples.

Magnetic resonance in medicine

Shang H, Skloss T, von Morze C, Carvajal L, Van Criekinge M, Milshteyn E, Larson PE, Hurd RE, Vigneron DB

Concentric rings K-space trajectory for hyperpolarized (13)C MR spectroscopic imaging.

Magnetic resonance in medicine

Jiang W, Lustig M, Larson PE

Simultaneous imaging of radiation-induced cerebral microbleeds, arteries and veins, using a multiple gradient echo sequence at 7 Tesla.

Journal of magnetic resonance imaging : JMRI

Bian W, Banerjee S, Kelly DA, Hess CP, Larson PE, Chang SM, Nelson SJ, Lupo JM

BI-07HYPERPOLARIZED [1-13C] GLUTAMATE: A METABOLIC IMAGING BIOMARKER OF IDH1 MUTATIONAL STATUS IN GLIOMA.

Neuro-oncology

Myriam Chaumeil, Peder Larson, Sarah Woods, Larry Cai, Pia Eriksson, Aaron Robinson, Janine Lupo, Daniel Vigneron, Sarah Nelson, Russell Pieper, Joanna Phillips, Sabrina Ronen

Chemical shift separation with controlled aliasing for hyperpolarized (13) C metabolic imaging.

Magnetic resonance in medicine

Shin PJ, Larson PE, Uecker M, Reed GD, Kerr AB, Tropp J, Ohliger MA, Nelson SJ, Pauly JM, Lustig M, Vigneron DB

Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites.

Magnetic resonance in medicine

Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PEZ

Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance.

Diabetes

Keshari KR, Wilson DM, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ

Magnetic resonance imaging for lung cancer screen.

Journal of thoracic disease

Wang YX, Lo GG, Yuan J, Larson PE, Zhang X

A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging.

Magnetic resonance in medicine

Tang S, Jiang W, Chen HY, Bok R, Vigneron DB, Larson PE

Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels.

Journal of magnetic resonance imaging : JMRI

Li Y, Larson P, Chen AP, Lupo JM, Ozhinsky E, Kelley D, Chang SM, Nelson SJ

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma.

Cancer research

Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM

Kinetic and perfusion modeling of hyperpolarized (13)C pyruvate and urea in cancer with arbitrary RF flip angles.

Quantitative imaging in medicine and surgery

Bahrami N, Swisher CL, Von Morze C, Vigneron DB, Larson PE

Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion.

Magnetic resonance in medicine

Shin PJ, Larson PE, Ohliger MA, Elad M, Pauly JM, Vigneron DB, Lustig M

Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain.

Magnetic resonance in medicine

Park I, Larson PE, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ

High resolution (13)C MRI with hyperpolarized urea: in vivo T(2) mapping and (15)N labeling effects.

IEEE transactions on medical imaging

Reed GD, von Morze C, Bok R, Koelsch BL, Van Criekinge M, Smith KJ, Larson PE, Kurhanewicz J, Vigneron DB

Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate.

Science translational medicine

Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA

Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Xing Y, Reed GD, Pauly JM, Kerr AB, Larson PE

WE-C-116-02: High Resolution C-13 MRI with Hyperpolarized [C-13,N-15] Urea.

Medical physics

G Reed, C von Morze, R Bok, B Koelsch, K Smith, M van Criekinge, P Larson, J Kurhanewicz, D Vigneron

Diffusion MR of hyperpolarized 13C molecules in solution.

The Analyst

Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J

Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.

Magnetic resonance in medicine

Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB

Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI).

Journal of magnetic resonance imaging : JMRI

Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB

Non-invasive in vivo assessment of IDH1 mutational status in glioma.

Nature communications

Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM

Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer.

Magnetic resonance imaging

Larson PE, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB

Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer.

Magnetic resonance imaging

Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB

A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Larson PE, Kerr AB, Swisher CL, Pauly JM, Vigneron DB

Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T.

Magnetic resonance imaging

von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB

A first-in-human phase I imaging study using hyperpolarized 1 c-13 pyruvate (h-Py) in patients (pts) with localized prostate cancer (l-PCa).

Journal of Clinical Oncology

Andrea Lynne Harzstark, Vivian K. Weinberg, Krystyna Grycz, Ralph E. Hurd, Jan Henrik Ardenkjaer-Larsen, Jonathan Murray, Albert Chen, Marcus Ferrone, Ilwoo Park, Galen Reed, Pamela N. Munster, Eric Jay Small, Lucas E. Carvajal, Mark E. VanCriekinge, Peder E. Larson, Jose Chang, Robert A. Bok, Sarah J. Nelson, Daniel B. Vigneron, John V. Kurhanewicz

A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Reed GD, Larson PE, Morze Cv, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB

Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea.

Magnetic resonance imaging

von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB

Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging.

Proceedings of the National Academy of Sciences of the United States of America

Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM

Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging.

IEEE transactions on medical imaging

Larson PE, Kerr AB, Reed GD, Hurd RE, Kurhanewicz J, Pauly JM, Vigneron DB

In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine.

Magnetic resonance imaging

Hu S, Zhu M, Yoshihara HA, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PE, Kurhanewicz J, Vigneron DB

Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study.

Journal of magnetic resonance imaging : JMRI

Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S

13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.

Cell metabolism

Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A

Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate.

Journal of magnetic resonance (San Diego, Calif. : 1997)

von Morze C, Reed G, Shin P, Larson PE, Hu S, Bok R, Vigneron DB

Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models.

Journal of magnetic resonance imaging : JMRI

von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB

Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S

Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies.

Magnetic resonance in medicine

Larson PE, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB

Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor.

Cancer research

Dafni H, Larson PE, Hu S, Yoshihara HA, Ward CS, Venkatesh HS, Wang C, Zhang X, Vigneron DB, Ronen SM

Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J

Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI.

Magnetic resonance in medicine

Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB

3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer.

Magnetic resonance in medicine

Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB

Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors.

Neuro-oncology

Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ

Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging.

Journal of the American Chemical Society

Keshari KR, Wilson DM, Chen AP, Bok R, Larson PE, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J

Anisotropic field-of-view shapes for improved PROPELLER imaging.

Magnetic resonance imaging

Larson PE, Lustig MS, Nishimura DG

Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Larson PE, Kerr AB, Chen AP, Lustig MS, Zierhut ML, Hu S, Cunningham CH, Pauly JM, Kurhanewicz J, Vigneron DB

IEEE Transactions on Medical Imaging

Anisotropic Field-of-views in radial imaging

Peder E. Z. Larson, Paul T. Gurney, and Dwight G. Nishimura

Using adiabatic inversion pulses for long-T2 suppression in ultrashort echo time (UTE) imaging.

Magnetic resonance in medicine

Larson PE, Conolly SM, Pauly JM, Nishimura DG

Designing long-T2 suppression pulses for ultrashort echo time imaging.

Magnetic resonance in medicine

Larson PE, Gurney PT, Nayak K, Gold GE, Pauly JM, Nishimura DG