Yan Li, PhD

Assistant Professor, Neuroimaging Research Group
Radiology
+1 415 514-2104

Dr. Yan Li joined UCSF Radiology and Biomedical Imaging as an Assistant Professor in March 2019. Dr. Li received her medical degree from Shanghai Jiao Tong University in China, Master of Science in Biochemistry from McGill University in Canada, and PhD from the UCSF/UC Berkeley Joint Graduate Program in Bioengineering. Before accepting current position, she worked in the laboratory of Dr. Sarah Nelson as a post-doctoral fellow and later as an assistant research scientist.

Dr. Yan Li’s research focuses on developing methods for obtaining reliable metabolic information from the brain in order to characterize spatial and temporal heterogeneity and the biologic behavior during disease time for brain tumors, psychiatric and neurologic diseases. This includes the development of new methods for obtaining whole brain metabolites and tools for generating metrics of brain neurotransmitters using 3T and 7T MR scanners, implementation of statistical methods to relate metabolic metrics to clinical outcome or measures, and integrating steady state 1H metabolic imaging with PET, hyperpolarized 13C and advanced MR imaging parameters in order to elucidate the underlying normal and abnormal biological process.

Publications: 

NIMG-47. METABOLIC CHARACTERIZATION OF IDH MUTANT LOWER GRADE GLIOMA USING SPECTROSCOPIC IMAGING OPTIMIZED FOR 2-HYDROXYGLUTARATE DETECTION.

Neuro-oncology

Marisa LaFontaine, Adam Autry, Elizabeth Philips, Llewellyn Jalbert, Javier Villanueva-Meyer, Susan Chang, Yan Li

NIMG-50. INITIAL EXPERIENCE: DETECTION OF ABERRANT HYPERPOLARIZED [1-13C]PYRUVATE METABOLISM IN PATIENTS WITH GBM PRIOR TO RESECTION.

Neuro-oncology

Adam Autry, Jeremy Gordon, Marisa LaFontaine, Hsin-Yu Chen, Javier Villanueva-Meyer, Susan Chang, Jennifer Clarke, Duan Xu, Janine Lupo, Peder Larson, Daniel Vigneron, Yan Li

CBMT-26. SERIAL CHARACTERIZATION OF HYPERPOLARIZED [1-13C]PYRUVATE METABOLISM IN PATIENTS WITH GLIOMA AND THE INFLUENCE OF BEVACIZUMAB.

Neuro-oncology

Adam Autry, Jeremy Gordon, Hsin-Yu Chen, Marisa Lafontaine, Javier Villanueva-Meyer, Susan Chang, Duan Xu, Peder Larson, Daniel Vigneron, Yan Li

CBMT-36. INITIAL EXPERIENCE WITH HYPERPOLARIZED [2-13C]PYRUVATE MR IMAGING IN PATIENTS WITH IDH-MUTANT GLIOMA.

Neuro-oncology

Adam Autry, Brian Chung, Hsin-Yu Chen, Jeremy Gordon, Marisa Lafontaine, Susan Chang, Javier Villanueva-Meyer, Peder Larson, Daniel Vigneron, Yan Li

NIMG-33. TUMOR GROWTH AND MRI TRAJECTORIES IN GRADE II AND III GLIOMA.

Neuro-oncology

Tracy Luks, Yan Li, Paula Alcaide-Leon, Marisa Lafontaine, Angela Jakary, Susan Chang, Javier Villanueva-Meyer

NIMG-57. SERIAL HYPERPOLARIZED 13C PYRUVATE AND 1H METABOLIC IMAGING IN RECURRENT HIGH-GRADE GLIOMA.

Neuro-oncology

Javier Villanueva-Meyer, Adam Autry, Jeremy Gordon, Hsin-Yu Chen, Marisa Lafontaine, Susan Chang, Duan Xu, Peder Larson, Daniel Vigneron, Yan Li

DIPG-31. FEASIBILITY OF HYPERPOLARIZED 13C METABOLIC IMAGING IN PEDIATRIC PATIENTS WITH DIPG AND OTHER CNS CANCERS.

Neuro-oncology

Adam Autry, Ilwoo Park, Hsin-Yu Chen, Jeremy Gordon, Cassie Kline-Nunnally, Daniel Vigneron, Janine Lupo, Yan Li, Duan Xu, Sabine Mueller

NIMG-08. REPRODUCIBILITY OF HYPERPOLARIZED C-13 METABOLIC IMAGING IN PATIENTS WITH GLIOMA.

Neuro-oncology

Adam Autry, Jeremy Gordon, Marisa Lafontaine, Javier Villanueva-Meyer, Daniel Vigneron, Susan Chang, Sarah Nelson, Yan Li

NIMG-24. DIFFUSION MRI PRECURSORS TO PROGRESSION IN GRADE II AND III GLIOMA.

Neuro-oncology

Tracy Luks, Yan Li, Marisa Lafontaine, Angela Jakary, Gaurav Inamdar, Michael Wahl, Susan Chang, Sarah Nelson, Javier Villanueva-Meyer

NIMG-66. COMPARISON OF STEADY STATE AND DYNAMIC BRAIN METABOLISM BY USING 1H MRSI AND HYPERPOLARIZED [1-13C]PYRUVATE IMAGING IN PATIENTS WITH GLIOMA.

Neuro-oncology

Yan Li, Adam Autry, Jeremy Gordon, Jason Crane, Beck Olson, Marisa Lafontaine, Ilwoo Park, Javier Villanueva-Meyer, Daniel Vigneron, Susan Chang, Sarah Nelson

Reliable and Reproducible GABA Measurements Using Automated Spectral Prescription at Ultra-High Field.

Frontiers in human neuroscience

Li Y, Bian W, Larson P, Crane JC, Parvathaneni P, Nagarajan S, Nelson SJ

Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen.

Neuro-oncology

Nelson SJ, Kadambi AK, Park I, Li Y, Crane J, Olson M, Molinaro A, Roy R, Butowski N, Cha S, Chang S

Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab.

Journal of neuro-oncology

Nelson SJ, Li Y, Lupo JM, Olson M, Crane JC, Molinaro A, Roy R, Clarke J, Butowski N, Prados M, Cha S, Chang SM

Association of Diffusion and Anatomic Imaging Parameters with Survival for Patients with Newly Diagnosed Glioblastoma Participating in Two Different Clinical Trials.

Translational oncology

Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ

Imaging tumor metabolism using in vivo magnetic resonance spectroscopy.

Cancer journal (Sudbury, Mass.)

Li Y, Park I, Nelson SJ

NI-61VOLUMETRIC H-1 MR METABOLIC IMAGING FOR DEFINITION OF LESION BURDEN AND PREDICTION OF OUTCOME FOR PATIENTS WITH NEWLY DIAGNOSED GBM.

Neuro-oncology

Sarah Nelson, Yan Li, Michael Prados, Nicholas Butowski, Jennifer Clarke, Susan Chang

Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels.

Journal of magnetic resonance imaging : JMRI

Li Y, Larson P, Chen AP, Lupo JM, Ozhinsky E, Kelley D, Chang SM, Nelson SJ

Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Nelson SJ, Ozhinsky E, Li Y, Park Iw, Crane J

Survival analysis in patients with newly diagnosed glioblastoma using pre- and postradiotherapy MR spectroscopic imaging.

Neuro-oncology

Li Y, Lupo JM, Parvataneni R, Lamborn KR, Cha S, Chang SM, Nelson SJ

Advances in ultra-high field MRI for the clinical management of patients with brain tumors.

Current opinion in neurology

Lupo JM, Li Y, Hess CP, Nelson SJ

Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme.

Neuro-oncology

Li Y, Lupo JM, Polley MY, Crane JC, Bian W, Cha S, Chang S, Nelson SJ

Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T.

Journal of magnetic resonance imaging : JMRI

Li Y, Srinivasan R, Ratiney H, Lu Y, Chang SM, Nelson SJ

Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T.

Magnetic resonance in medicine

Li Y, Chen AP, Crane JC, Chang SM, Vigneron DB, Nelson SJ

Considerations in applying 3D PRESS H-1 brain MRSI with an eight-channel phased-array coil at 3 T.

Magnetic resonance imaging

Li Y, Osorio JA, Ozturk-Isik E, Chen AP, Xu D, Crane JC, Cha S, Chang S, Berger MS, Vigneron DB, Nelson SJ